Durolane Patient Treatment Guide

Were you recently diagnosed with Osteoarthritis (OA)?

If so, understanding your treatment options can help you spend less time seeking relief and more time doing what you love.

Or if you have not been diagnosed, you may recognize these common OA symptoms:

• Joint pain
• Joint stiffness and swelling
• Reduced joint range of motion and flexibility
• Joint weakness
• Grating sensations when moving your joints
• Fatigue
• Anxiety and depression

Early diagnosis of OA and proactive treatment can help you manage your OA effectively.

Starting your OA treatment pathway

No single OA therapy works for everybody, and treatments vary in terms of risks, side effects, and duration of benefits. It is important to discuss your OA care options with your doctor.

Many doctors recommend an approach that includes a combination of treatments, such as:

• Physical therapy
• Exercise
• Weight management
• Anti-inflammatory medications
• Corticosteroid or platelet rich plasma (PRP) injection therapies
• Hyaluronic acid (HA) injection therapies, such as DUROLANE

Understanding your OA treatment options

With so many treatments available, finding the right OA treatment pathway
may seem overwhelming. The following chart can help you understand some
of your options. Always consult your doctor and/or a qualified and recognized
medical professional before starting any OA treatment.

Treatment	Potential Benefits	Disadvantages
Weight management3	May reduce inflammation and pressure on joints, increase energy and activity, slow OA progression, and improve your chances of OA flare remission	No known disadvantages
Joint mobility and strength training	May decrease pain, strengthen muscles, and improve flexibility and balance	Too much exercise may cause excessive pain
Vitamins and supplements such as glucosamine and vitamin D3,4	May reduce inflammation	Minor gastrointestinal events
Heat therapy, such as a heating pad, steam shower, or warm bath	May relieve joint stiffness and muscle aches	Should not be used during an OA flare
Painkillers, such as acetaminophen4	May help manage pain	May cause liver toxicity
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac, celecoxib and naproxen	May reduce joint inflammation, pain, and swelling	Excessive or long-term use increases the risk of adverse events affecting upper gastrointestinal tract, kidney, or cardiovascular functions
Opioids, such as oxycodone, hydrocodone, codeine, and morphine5	May reduce joint inflammation, pain, and swelling in more severe cases	Increases the risk of cardiovascular adverse events, fractures, and hospitalizations; may lead to addiction
Intra-articular corticosteroids	May provide immediate relief of OA pain and reduce joint inflammation	Not recommended for repeat use
Intra-articular hyaluronic acid injections5,9	May provide long-lasting pain relief, while also improving joint function and range of motion.	Variability in results depending on HA chemical composition; risk of pain and stiffness after treatment

Where DUROLANE fits in your OA treatment pathway

If you do not get adequate pain relief from treatments such as oral medications,
physical therapy, or corticosteroid injections, you may be a good candidate
for DUROLANE

DUROLANE is a high molecular weight, single-injection HA therapy.8
HA is found naturally throughout the body. It is an important component
of synovial fluid, which provides lubrication and cushioning in healthy joints.

The HA in DUROLANE has the same composition as the natural HA that
your body produces, but it’s in a highly concentrated formulation that has
been uniquely stabilized to resist degradation.

Receiving your DUROLANE treatment

What makes DUROLANE different?

As a patient, you may be presented with different options to treat OA
without knowing how each option can help you. The following information
can give you a clear understanding of DUROLANE’s design and benefits.

These qualities mean that DUROLANE
provides extra cushioning and improved
range of motion. Because it is resistant to
degradation, DUROLANE also may provide
longer-lasting pain relief than other OA
treatments

Is DUROLANE right for you?

You may be prescribed DUROLANE if you are:

1. Diagnosed with mild to moderate OA
2. Diagnosed with OA in the knee, hip, shoulder, ankle, wrist, fingers, or toes*⁹
3. A nonresponder to alternative OA treatments¹⁷
4. Allergic to animal-sourced products and in need of a synthetic product¹⁷
5. Motivated to get back to your normal daily activities
6. Looking to delay joint replacement surgery, with a treatment safe for repeated use over time^6,18
7. Not a surgical candidate and needing a nonoperative treatment for long lasting pain relief

Many factors may influence which OA therapies work best for you. So talk with
your doctor to find out if DUROLANE should be part of your treatment pathway.

After receiving your DUROLANE treatment

Your doctor will provide you with post-injection treatment guide and care
instructions.

The most common side effects of treatment with DUROLANE are mild to
moderate pain, swelling, or stiffness for up to one week after the injection.
Placing a cold pack on the site for 10 to 15 minutes may reduce these
effects. If symptoms last more than a week, contact your doctor.

You may be advised to avoid strenuous activity (such as tennis, jogging,
and long walks) for two days after the injection.

DUROLANE can give you freedom from knee OA pain, improving joint
function and quality of life as early as two weeks after treatment.

Five ways DUROLANE may affect your OA treatment pathway:

Predictable treatment outcomes

• Evidence-based treatment
• Powerful and lasting improvement in quality of life

Cost-effectiveness

• Single injection regimen
• Reduction in indirect costs, such as transportation and fuel
• Less time

Flexibility

• Minimal clinic visits
• Easier for patients with mobility or transportation concerns

Proven safety and effectiveness

• Non-avian source and minimal cross-linking, resulting in a low risk
  of adverse events or allergic reactions

Delay of total joint replacement

• Nonoperative treatment for patients who cannot have surgery
• Nonoperative treatment option while waiting for surgical intervention
  due to backlogs